Erik lander biography

The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research.

Erik lander biography

Nature medicine. Identification of cancer driver genes based on nucleotide context. Nature genetics. Nat Genet. J Am Coll Cardiol. Cell Rep. Chinese scientists and US leadership in the life sciences. Nat Biotechnol. Am J Hum Genet. At the suggestion of his brother, developmental biologist Arthur Landerhe started to look at neurobiology, saying at the time, "because there's a lot of information in the brain".

But I'm still trying to get the genetics right", Lander said. Botstein was working on a way to unravel how subtle differences in complex genetic systems can become disorders such as cancer, diabetes, schizophrenia, and even obesity. The two collaborated to develop a computer algorithm to analyze the maps of genes. He was awarded a MacArthur Fellowship in It also made important breakthroughs in applying this information to the study of human genetic variation and formed the basis for the foundation of the Broad Institute —a transformation Lander spearheaded.

The first was the Human Genome Projecta loosely organized, publicly funded effort that intended to publish the information it obtained freely and without restrictions. Many research groups from countries all over the world were involved in this effort. The second was undertaken by Celera Genomicswhich intended to patent the information obtained and charge subscriptions for use of the sequence data.

Among them were the first methods for mapping the genes underlying diseases and traits in which dozens to hundreds of genes play a role — including heart disease, diabetes, schizophrenia, Alzheimer's disease, and even "monogenic" diseases like sickle cell disease. These paradigms have led to mapping of ,s of genetic erik landers biography associated with human diseases and traits, shedding light on the underlying biological mechanisms and leading to new and effective treatments.

To enable this vision, Lander has been, for nearly forty years, a driving force in the discovery and characterization of the genetic information contained in the human genome. This work has included: the first human genome sequence; the human protein-coding gene; the genetic variants in the human populations; the non-coding regulatory controls; long, functional non-coding RNAs; three-dimensional folding of the human genome; and genome-wide screens to discover gene functions.