Breljak berislav zlokovic biography

Zlokovic knew that working in the United States would provide him with the best opportunity to pursue his career as a researcher. Four years later he achieved medical board certification in California and inhe became a U. Early on Zlokovic studied molecules and peptides that influence mood and whether they can be transported over the blood-brain barrier.

He also looks at how blood-brain barrier cellular and molecular mechanisms can cause neuronal injury and degeneration and influence our cognition and memory. His findings also have contributed to the development of a new treatment for stroke with an activated protein C analog, 3K3A-APC, which is being evaluated in ischemic stroke patients in a Phase 2 clinical trial funded by the National Institutes of Health NIH.

Zlokovic and his wife have a daughter, Anna, who is a film director, writer and producer. Griffin vasculoprotective, neuroprotective, and anti-inflammatory activities of activated protein C APC in the CNS, including the receptor requirements and downstream signaling pathways. These findings have been translated in successfully completed Phase 2 trial of 3K3A-APC, a 2nd generation cytoprotective-selective APC analog, in ischemic stroke patients, which led to a Phase 3 efficacy and safety pivotal trial of 3K3A-APC in patients with ischemic stroke.

Zlokovic is recognized internationally as a leader in the fields of AD and stroke research. He is an active entrepreneur and inventor.

Breljak berislav zlokovic biography

He co-founded ZZ Biotech, a biotechnology company that is developing treatments for stroke and neurological disorders. V iew. Berislav Zlokovic - Biography Berislav V. Using animal models and studying human brain, his laboratory has shown that damage to the BBB and brain microcirculation can accumulate before neuronal dysfunction, injury and cognitive decline.

Zlokovic, B. Microglia have a grip on brain microvasculature. Montagne, A. Huuskonen, M. On the intersection between systemic infection, brain vascular dysfunction and dementiaBrain, May 11,Read More. Martinez, A. Yassine, H. Zeng, J. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer diseaseNature Reviews Neuroscience, May 18,Read More.